Phase transitions of drug substances to polymorphs or pseudopolymorphs sometimes occur because of temperature and humidity effects. Polymorphs and pseudopolymorphs can differ in solubility and absorption time, so it is important to control and evaluate them during drug development and manufacturing. Here is an example where we calculated the amount of polymorph impurities in a drug substance using a high-speed 1D detector, which can obtain intensity data sufficient for qualitative and quantitative analysis in a short period of time, with a benchtop X-ray diffractometer to determine the diffraction data and perform quantitative analysis by the calibration method.
Advanced state-of-the-art high-resolution XRD system powered by Guidance expert system software
Highly versatile multipurpose X-ray diffractometer with built-in intelligent guidance
New 6th-generation general purpose benchtop XRD system for phase i.d and phase quantification
High-performance, multi-purpose XRD system for applications ranging from R&D to quality control
Laboratory micro-spot XRD residual stress analysis with both iso- and side-inclination methods
2D X-ray detector with latest semiconductor technology designed for home lab diffractometers