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XtaLAB Synergy-R/DW
  • Faster, accurate data collection due to high-speed kappa goniometer, high flux rotating anode X-ray source, fast, low-noise X-ray detector, and highly optimized instrument control software.
  • Improve your ability to investigate small samples due to the increased flux from the rotating anode X-ray source as well as the extreme low-noise of the HyPix X-ray detectors. Noise fee images mean you can count longer for weakly diffracting crystals without a loss in data quality arising from detector noise.
  • Enhance your ability to resolve large unit cells, twins or incommensurate lattices when you select the optional motorised variable beam slit in order to alter divergence to adapt the source to your sample’s requirements.
  • Highest level of user safety with multiply redundant electromechanical safety circuits built into the ergonomically designed radiation enclosure.
  • Minimize your downtime by utilizing built-in online diagnostics and troubleshooting to diagnose and fix almost all problems without a site visit.

High-flux rotating anode X-ray diffractometer

A powerful and fast system for macromolecular crystallography

XtaLAB Synergy-R

The XtaLAB Synergy-R is the most powerful rotating anode microfocus single crystal X-ray diffractometer available in a compact cabinet. For protein crystallographers who wish to have a powerful, well-integrated diffractometer and only need to use one port of the rotating anode, the XtaLAB Synergy-R provides the perfect combination of high-flux performance with a low-noise HPC X-ray detector. Combining high-performance components, the XtaLAB Synergy-R allows you to collect high-quality diffraction data on even the weakest of samples. Moreover, the XtaLAB Synergy-R offers a number of design features that extend the experimental flexibility to address the most challenging samples. The XtaLAB Synergy-R system is a tightly integrated single crystal X-ray diffractometer with four basic areas of technology: a high-flux, low-maintenance PhotonJet-R X-ray source with continuously variable divergence slit, a high-precision kappa goniometer, Rigaku’s Hybrid Photon Counting (HPC) X-ray detector, the HyPix-6000HE (or optionally the HyPix-Arc 150° or Dectris EIGER 4M) with extremely low readout noise, no dark noise and high dynamic range, and the CrysAlisPro diffraction software package with sophisticated algorithms to tie the hardware together to minimize the time it takes to measure data from protein crystals.

HPC direct detection X-ray detector

HPC detectors are ideal for macromolecular crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need for the intermediate step of converting X-ray photons to light with a phosphor or scintillator. As a result, HPCs have high dynamic range, fast readout speed and extremely low noise. Additionally, HPC X-ray detectors have a top-hat point spread function of a single pixel. These combined features, along with shutterless data collection, mean that you can collect more accurate diffraction data, faster. As a result, the XtaLAB Synergy Custom systems offer outstanding performance for macromolecular single crystal X-ray diffraction experiments.


The PhotonJet-R comes from the same pedigree as the MicroMax-007 HF, of which there are well over 1000 units in use around the world. The PhotonJet-R X-ray source applies the lessons learned over the development and lifetime of the MicroMax™-007 rotating anode to produce a new generation, high performance rotating anode source. With the source mounted directly onto the goniometer the XtaLAB Synergy-R provides a stable and robust solution which ensures consistently high performance. Confocal optics designed by Rigaku Innovative Technologies, offer high brillliance and an optional continuously variable slit assembly give high brilliance or low divergence as needed to cater to any sample.

Proven Reliability

The PhotonJet-R source was designed with reliability in mind. Clever Rigaku engineering makes filament changes easy, like swapping a printer cartridge, with no need to realign the source each time. Scheduled maintenance involves one annual visit from a Rigaku engineer, as with all XtaLAB Synergy diffractometers, and typically takes 1-2 days. With the anode exchange program, you get the benefit of rotating anode power with the convenience of sealed tubes.

Beam Conditioning

Where overlapping peaks are a concern, e.g. large unit cells, proteins, twinned or incommensurate, high beam divergence is undesirable. On PhotonJet sources, a software controlled, motorized variable beam slit is available as an option to alter divergence to adapt the source to your sample’s requirements. For those samples where intensity matters most, the slit can be fully opened giving the highest flux. For those where peak sharpness and overlap are factors, the beam can be limited to a divergence anywhere between 1 to 10 mrad.

CrysAlisPro v40

The XtaLAB Synergy-R comes complete with CrysAlisPro, our user-inspired data collection and data processing software for single crystal analysis. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control. Of particular interest to protein crystallographers is the ability to operate CrysAlisPro either in a protein or small molecule dedicated workflow. Popular third-party protein data processing packages can easily process diffraction data if desired. CrysAlisPro combines automated crystal screening, the fastest and most accurate strategy software available, concurrent data reduction and automatic small molecule structure solution. Visual feedback is provided for each step with clear, color-coded guidance so that both novices and experts can collect high-quality data in the shortest time possible.


If a XtaLAB Synergy-R diffractometer is to be shared with small molecule crystallographers, AutoChem is included as the ultimate productivity tool for small molecule chemists, offering fast, fully automatic structure solution and refinement during data collection. Developed in collaboration with OlexSys Ltd (Durham University, UK), AutoChem works in conjunction with Olex² where more advanced structure solution and refinement functionality exists. AutoChem is seamlessly integrated within CrysAlisPro, and forms an integral part of our ‘What is this?’ feature. The ‘What is this?’ feature gives you structures quickly and ensures you are not wasting time collecting full datasets on known samples or starting materials. It is an alternative pre-experiment option, which is used to plan your full data collections.

Product name XtaLAB Synergy-R
Core attributes Microfocus rotating anode X-ray source diffractometer with hybrid pixel array detector and kappa goniometer
Detectors HyPix-6000HE, the large theta coverage HyPix-Arc 150°,  or Dectris EIGER 4M
X-ray source PhotonJet-R X-ray source with MicroMax™-007 rotating anode which incorporates a new mirror design and new alignment hardware.
Goniometer Fast kappa geometry goniometer that allows data collection scan speeds of up to 10°/sec.
Accessories Oxford Cryostream 800, Oxford Cobra, XtalCheck-S
Computer External PC, MS Windows® OS, CrysAlisPro Software
Core dimensions 1300 (W) x 1875 (H) x 850 (D) (mm)
Mass 600 kg (core unit)
Power requirements 1Ø, 200-230 V, 20 A 

Options and Accessories

The following accessories are available for this product
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Papers published using the XtaLAB Synergy-R

  1. Yang Liu, Yan-Cong Chen, Jiang Liu, Wen-Bin Chen, Guo-Zhang Huang, Si-Guo Wu, Jin Wang, Jun-Liang Liu, Ming-Liang Tong Cyanometallate-Bridged Didysprosium Single-Molecule Magnets Constructed with Single-Ion Magnet Building Block Inorganic Chemistry 2020 59(1) , 687-694
  2. Cui-Juan Zhang, Kai-Ting Lian, Si-Guo Wu, Yang Liu, Guo-Zhang Huang, Zhao-Ping Ni, Ming-Liang Tong The substituent guest effect on four-step spin-crossover behavior Inorg. Chem. Front. 2020
  3. Jingjing Yang, Xing Liu, Zemei Liu, Long Wang, Jing Sun, Zhen Guo, Huixia Xu, Hua Wang, Bo Zhao, Guohua Xie Protonation-induced dual fluorescence of a blue fluorescent material with twisted A–π–D–π–A configuration J. Mater. Chem. C 2020
  4. Neil Hearne, Mark M. Turnbull, Christopher P. Landee, Elizabet M. van der Merwe, Melanie Rademeyer Halide-bi-bridged polymers of amide substituted pyridines and -pyrazines: polymorphism, structures, thermal stability and magnetism CrystEngComm 2019 21(12) , 1910-1927
  5. Liang Qiao, Xiao-Gang Chen, Ji-Xing Gao, Yong Ai Three new quinuclidine-based structures: second harmonic generation response for 1,2-bis(1-azoniabicyclo[2.2.2]octan-3-ylidene)hydrazine dichloride Acta Cryst. C 2019 75(6) , 728-733
  6. Long-Fei Wang, Wei-Man Zhuang, Guo-Zhang Huang, Yan-Cong Chen, Jiang-Zhen Qiu, Zhao-Ping Ni, Ming-Liang Tong Spin-crossover modulation via single-crystal to single-crystal photochemical [2 + 2] reaction in Hofmann-type frameworks Chem. Sci. 2019 10(32) , 7496-7502
  7. Qiang Guo, Xiali Si, Yuntao Shi, Hongshuai Yang, Xinyu Liu, Hong Liang, Pengfei Tu, Qingying Zhang Glucoconjugated Monoterpene Indole Alkaloids from Uncaria rhynchophylla Journal of Natural Products 2019 82(12) , 3288-3301